Pii: S1010-7940(99)00224-9

Objective: Simple irrigation has proven to be an ef®cient method to treat postpneumonectomy empyema provided that bronchopleural ®stula is not present or successfully closed. However, with this treatment modality, infected material inside the thoracic cavity is not removed and this can be a potential source of empyema recurrence if the patient's immune system is compromised. The removal of the infected material should result in a lower recurrence rate. Methods: As soon as diagnosis of postpneumonectomy empyema was established, a chest tube drainage was inserted. A concomitant bronchopleural ®stula was evaluated bronchoscopically. If the ®stula was smaller than 3 mm, bronchoscopic sealing with ®brin glue (Tissucol, Immuno, Vienna) was initiated. Fistulas closed surgically were excluded from this analysis. The thoracic cavity was cleared of infected material by videothoracoscopy and bacteriological samples were taken. Immediately after operation antibiotic irrigation according to culture sensitivity was started via a single chest tube drainage twice a day. After instillation of antibiotics the drain was kept clamped for 3 h. Culture samples were obtained twice a week. Empyema was considered eradicated, if three subsequent cultures showed no bacterial growth. After drain removal the patients were kept in hospital for another week and observed for clinical signs of infection; WBC and CRP were controlled. Results: Nine patients (®ve men, four women) between 55 and 72 years (mean 61, SD 6), all initially operated on for malignancy, were successfully treated with this regimen. In three cases a concomitant bronchopleural ®stula was successfully closed before videothoracoscopy. The interval between primary operation and empyema was between 7 and 436 days (mean 93, SD 141). There was no postoperative mortality and no procedure related morbidity. Operating time ranged from 45 to 165 min (mean 92.7, SD 36.6), the suction volume (consisting of blood, debris and pus) was 300 to 1000 ml (mean 880, SD 600). Duration of thoracic drainage was 12±38 days (mean 22, SD 9), duration of hospital stay after videothoracoscopy 21±46 days (mean 29, SD 9). During the followup period of 204-1163 days (mean 645, SD 407) no recurrence of tumour or empyema was observed. Conclusions: Videothoracoscopic debridement of the postpneumonectomy space with postoperative antibiotic irrigation of the pleural space is an ef®cient method to treat postpneumonectomy empyema, provided that a concomitant bronchopleural ®stula can be closed successfully. No early empyema or ®stula recurrence were observed. However, late recurrence may occur many years after operation, therefore close follow-up is indicated. q 1999 Elsevier Science B.V. All rights reserved.